Celeste 10mg Tablet

✔️ Uses of Celeste 10mg Tablet

Celeste 10mg Tablet is primarily used for the following conditions:

• Erectile Dysfunction
• Benign Prostatic Hyperplasia
• Pulmonary Arterial Hypertension (Pah)

✔️ How does Celeste 10mg Tablet work?

Celeste 10mg Tablet relaxes the smooth muscles by inhibiting Phosphodiesterase type-5. This results in the increase of cyclic guanosine monophosphate (cGMP) which relaxes the smooth muscles and increases the flow of blood.

✔️ Side Effects of Celeste 10mg Tablet

Common Side Effects of Celeste 10mg Tablet:

• Headache
• Back pain
• Muscle pain
• Pain in arms and legs
• Flushing of the face
• Nasal congestion
• Indigestion
• Swelling of the face
• Uterine bleeding
• Nausea
• Stomach pain
• Acidity

Uncommon Side Effects:

• Dizziness
• Vomiting
• Blurred vision
• Eye pain
• Difficulty in breathing
• Blood in urine
• Palpitation (racing heartbeat)
• Changes in blood pressure (high/low)
• Nasal bleeds
• Tinnitus (ringing in ears)
• Tiredness

Rare Side Effects:

• Bleeding from penis
• Blood in semen

Stop taking Celeste 10mg Tablet and contact your doctor immediately if you experience any of the following severe side effects:

• Severe allergic reaction (such as wheeziness, difficulty in breathing, swelling of the face, lips, eyelids, or throat)
• Prolonged or painful erection (priapism)
• Chest pain
• Sudden decline or loss of vision
• Decreased hearing or sudden hearing loss

✔️ Erectile Dysfunction (ED):

Erectile dysfunction is the inability to achieve or maintain a firm enough erection for sexual intercourse. It can result from physical or psychological factors, including anxiety, depression, stress, low self-esteem, and certain lifestyle factors such as smoking, excessive alcohol consumption, obesity, physical inactivity, and high blood pressure. Symptoms of ED include difficulty in getting an erection, difficulty in keeping an erection during sexual activity, and reduced sexual desire.

✔️ Benign Prostatic Hyperplasia (BPH):

Benign prostatic hyperplasia, also known as prostate enlargement, is a non-cancerous growth of the prostate gland caused by an increase in the number of cells. This enlargement can lead to the compression of the urethra, resulting in urinary symptoms. BPH is commonly associated with aging and can cause issues with urination, including frequent urination, difficulty in starting and stopping urination, weak urinary stream, incomplete bladder emptying, and a sudden urge to urinate.

✔️ Pulmonary Arterial Hypertension (PAH):

Pulmonary arterial hypertension is a condition characterized by high blood pressure in the arteries of the lungs and heart. It occurs when the blood vessels in the lungs become narrowed or blocked, leading to increased strain on the heart. Symptoms of PAH may include chest pain, dizziness, fatigue, and swelling in the legs and ankles.

✔️ Quick Suggestions:

• Take Tadalafil about an hour before sexual activity, although you can take it anywhere between 30 minutes and 4 hours before. It's essential to follow your doctor's instructions regarding timing.
• Do not exceed the recommended dosage, and do not take it more than once a day.
• Tadalafil can also be used to treat the urinary symptoms associated with an enlarged prostate gland (BPH). Follow your doctor's recommendations for BPH treatment.
• Seek immediate medical attention if you experience an erection that persists for more than four hours after sexual intercourse, as this condition (priapism) can be harmful.
• Do not use Tadalafil if you have taken nitrates (medicines for angina or chest pain) recently, had a heart attack within the past three months, or experienced a stroke or heart failure within the past six months.

✔️ Indication

Celeste 10mg Tablet is a medication prescribed for two main purposes:

Treatment of Erectile Dysfunction (ED): This condition occurs when a man has difficulty achieving or maintaining an erection sufficient for sexual intercourse. Celeste 10mg Tablet helps by increasing blood flow to the penis, facilitating erections when sexual stimulation occurs.

Treatment of Benign Prostatic Hyperplasia (BPH): In older men, the prostate gland can enlarge and cause urinary symptoms. Celeste 10mg Tablet can help relieve some of these symptoms by relaxing the muscles in the prostate and bladder, making it easier to urinate.

✔️ Pharmacology

Pharmacodynamics: To combat Erectile Dysfunction (ED), Tadalafil takes on the villainous phosphodiesterase type 5 (PDE5) enzymes. By inhibiting PDE5, it allows cGMP to flourish, boosting erectile function. With more cGMP, smooth muscles relax, and blood surges into the corpus cavernosum, vanquishing ED.

Pharmacokinetics: After a single oral dose, Tadalafil's power peaks between 30 minutes and 6 hours (typically 2 hours). It's distributed throughout your body's tissues, with 94% binding to proteins. Fear not, only a tiny fraction appears in your semen. CYP3A4 helps metabolize it into a catechol metabolite, further transformed into methyl catechol and methyl catechol glucuronide. Tadalafil's clearance rate is 2.5 L/hr, and its heroic half-life is 17.5 hours. It's primarily expelled through feces (61%) and somewhat in urine (36%).

✔️ Dosage & Administration of Celeste 10mg Tablet

Tadalafil Dosage Guidelines:

As Needed Basis (Erectile Dysfunction):

• Start with 10 mg before engaging in sexual activity.
• Adjust between 5 mg to 20 mg based on your response.

Regular Basis (Pulmonary Arterial Hypertension):

• Take 40 mg (2 tablets of 20 mg) once daily.
• Do not split the dose into morning and evening.
• Can be taken with or without food.

Missed Dose? No Worries! If you miss a dose, don't fret. Just skip it and continue with your next scheduled dose. Keep the momentum going.

✔️ Interaction

Tadalafil is primarily processed by CYP3A4. Inhibitors of CYP3A4, like ketoconazole, can significantly increase Tadalafil levels in the bloodstream, potentially leading to more side effects. While specific interactions haven't been extensively studied, exercise caution when combining Tadalafil with protease inhibitors (e.g., ritonavir, saquinavir) and other CYP3A4 inhibitors (e.g., erythromycin, clarithromycin, itraconazole) since they may also raise Tadalafil levels, potentially increasing the risk of side effects.

✔️ Contraindications

• Allergy

✔️ Pregnancy & Lactation

Tadalafil Use During Pregnancy and Breastfeeding:

There is a lack of sufficient data on the use of Tadalafil in pregnant women. Whether Tadalafil or its metabolites are excreted in human breast milk is unknown. Therefore, it is not recommended for use by nursing mothers. If you are pregnant or breastfeeding, consult your healthcare provider for guidance before using Tadalafil.

✔️ Precautions & Warnings

It's important to discuss the following with your doctor before using Celeste 10mg Tablet:

• Heart Problems: If you have a history of heart problems, it's crucial to inform your doctor. Certain heart conditions may be affected by the use of Celeste 10mg Tablet.
• Genital Organ Deformities: If you have any physical deformities of the penis, it's important to let your doctor know. They can provide guidance on the safe use of Celeste 10mg Tablet.
• Vision or Hearing Loss: If you experience sudden vision loss or hearing loss after taking Celeste 10mg Tablet, contact your doctor immediately.
• Prolonged Erection: If your erection lasts for more than 4 hours after taking the medicine, it's a medical emergency. Seek immediate medical attention.
• Women: Celeste 10mg Tablet is not recommended for use in women.
• Kidney or Liver Problems: If you have kidney or liver problems, discuss this with your doctor. They may need to adjust your dosage or monitor your condition closely.
• Age: Celeste 10mg Tablet should not be used in children below 18 years of age.

✔️ Storage Conditions

Store in a cool and dry place away from light. Keep out of the reach of children.